Androgen Treatment Guidelines and Safety Concerns
NPWH/ISSWSH Women's Sexual Health Course for NPs (16-03)
Irwin Goldstein, MD, IF
• Identify abnormal testosterone values and the symptoms associated with it
• Describe treatment methods used to reestablish normal testosterone levels
Testosterone is a sex steroid hormone, naturally synthesized in the ovaries and adrenal glands from
cholesterol, and is present in declining values after age 30 years during post-pubertal life. Testosterone is
usually quite low just before, during, and after menopause. Normal testosterone values have been
associated with female sexual function and persistent diminished testosterone blood test values may occur
in menopause or following certain medications, have been associated with female sexual dysfunction.
Women with sexual dysfunction and persistent deficiency in testosterone can be identified through history
and physical examination and blood testing and can undergo bioidentical replacement treatment with
careful monitoring to reestablish sexual function.
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